Objective: To compare the clinical course and outcomes of hospitalized pregnant and non-pregnant patients with coronavirus disease 2019 (COVID-19). Design: Retrospective, single centre and case-control study. Setting: Renmin Hospital of Wuhan University, Wuhan, Hubei province, China Population: SARS-CoV-2-infected hospitalized 31 pregnant and 124 non-pregnant patients diagnosed between 1 January 1 and 7 May, 2020; final date of follow-up was Jul 8, 2020. Main outcomes and measures: Demographic, clinical, laboratory, radiological, treatments and outcomes were collected, analyzed and compared between the two groups. All neonates received detection for SARS-CoV-2. Results: Pregnant patients had higher leucocytes, neutrophil counts, C-reactive protein and lactate dehydrogenase level, but lower lymphocyte counts. More pregnant patients received antibiotic, corticosteroids and oxygen support. All seventeen neonates had negative results of severe acute respiratory syndrome coronavirus (SARS-CoV-2) without complications. All 31 pregnant and 124 non-pregnant patients, with similar clinical symptoms, intensive care unit admission and complications, had been discharged. Conclusion: Pregnant patients might have more obvious inflammatory response, cellular immune deficiency and potential tissue necrosis, but similar clinical manifestations and outcomes as compared with the non-pregnant patients. No evidence of neonatal infections and complications had been shown in this study. Timely and active management may be beneficial for improving the outcomes of pregnant women with COVID-19 and the neonates. Keywords: Coronavirus Disease 2019; COVID-19; Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2; Pregnant; Non-Pregnant. Tweetable abstract: Pregnant women had more obvious inflammatory response, cellular immune deficiency and potential tissue necrosis, but similar clinical manifestations and outcomes.