Persistently Elevated Urine β2-MG and Decreased BMD in a Patient with ADV-induced Hypophosphatemic Osteomalacia and Fanconi’s Syndrome After Drug Withdrawal

Yu Zhang; Jianfei Long; Shuangmei Tong; Wang Bin

doi:10.22541/au.161191700.02595613/v1

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Persistently Elevated Urine β2-MG and Decreased BMD in a Patient with ADV-induced Hypophosphatemic Osteomalacia and Fanconi’s Syndrome After Drug Withdrawal

Yu Zhang,
Jianfei Long,
Shuangmei Tong,
Wang Bin

Abstract

This is the first case of adefovir dipivoxil (ADV)-induced hypophosphatemic osteomalacia (HO) and Fanconi’s syndrome in which bone mineral density (BMD) is continuously reduced after drug discontinuation. Sustained elevation of urine β2-MG also supports the recent view that ADV-induced renal injury is not completely reversible.