Enteric and non-enteric adenoviruses in children with acute
gastroenteritis in Western India
Abstract
Human adenoviruses (HAdVs) are among the most important etiological
agents of acute gastroenteritis (AGE). HAdVs found in 5.2% of children
admitted for AGE between 2013 and 2016 in seven different hospitals
across four cities of Western India. The dominance of subgroup-F
(52.4%) strains was observed, followed by the occurrence of non-enteric
adenoviruses of the subgroup A (17.4%), C (11.4%), B (8.2%), and D
(3.2%). The subgroup-F strains were predominant in Ahmadabad (78.5%),
Mumbai (61.5%), and Surat (57.1%) cities, followed by subgroup A
strains. In Pune city, subgroup B and C strains were detected in 62.5%
of AGE patients, with none of the subgroup A strains. Clinically,
patients infected with enteric and non-enteric HAdV strains were
indistinguishable from each other. However, a high viral load was
observed in subgroup-F specimens as compared to non-subgroup-F. The
study highlights the need for viral load estimation to ascertain the
role of enteric and non-enteric HAdV strains associated with diarrheal
etiology.