Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect seen in children undergoing chemotherapy. Objective: To synthesize the evidence on physiotherapy for CIPN symptoms and deficits in children with cancer. Methods: A systematic review was conducted with the following PICOS approach: children with cancer, physiotherapy, control group or standard care, and randomized controlled trials and controlled clinical trials comprising range of motion, muscle strength, motor function, balance, gait, functional mobility, foot posture, pain, and adverse events outcomes. Searches were conducted in five electronic databases, reference lists, grey literature, and clinical trial websites in May 2023. Results: Nine full-text studies met the inclusion criteria. Although benefits were seen for some outcomes related to physical function, evidence is not at a stage to provide recommendations for clinical practice. Conclusion: Research is needed that includes CIPN-specific outcome measures to better inform the incidence, natural progression, and the benefits of physiotherapy interventions.