Objective Consideration of 99Tc-MDP and glucocorticoids are widely treated the patients with active RA in China, we wondered whether 99Tc-MDP or and oral glucocorticoids had an effect on lipid profiles in short term. Patients & Methods Patients with active RA were divided into two groups, who were treated with 99Tc-MDP or and GCs for 10 days. ESR, CRP and DAS28, lipid profiles were detected at baseline and the 10th day of treatment. Comparison of inflammatory markers and lipid profiles between treatment before and after was run by t test. The correlation coefficient between inflammatory markers and lipid levels was computed by nonparametric Spearman correlation analysis and line regression analysis. Results ESR, CRP and DAS28CRP or ESR were decreased significantly after treatment in the two groups. The levels of TG and ApoA1 were increased significantly in the group of 99Tc, while the ratio of ApoB/ApoA1 was decreased. In the group of 99Tc & GC, CHO, TG, and HDL-C, ApoA1 were increased after treatment, atherogenic index and the ratio of ApoB/ApoA1 both got down. Correlation analysis showed that CHO, LDL-C and ApoB inversely related to DAS28CRP or ESR in the group of 99Tc. HDL-C, TG and ApoA1, and ratio of ApoB/ApoA1 or atherogenic index were correlated with CRP, ESR or DAS28 ESR or CRP in the group of 99Tc & GC. Conclusions RA patients treated with 99Tc-MDP or and oral glucocorticoids occurred inflammatory attenuation, disease activity reduction as well as lipid profile changes.