The work required included traveling all over the U.S. to locate 250 members of the kindred. We obtained blood specimens and densitometry from 39 of them, and we collaborated with a genomics company to locate and identify the mutation. We applied for NIH funds, but we were not awarded funds to do the work, because the reviewers felt that we were unable to accomplish the work, and even if we did, it was not worth doing. I remain hopeful that further studies will ultimately show that a human sclerostin antibody will lead to a “cure” of osteoporosis.