Conclusions
This study demonstrates that when a surrogate mother carries the embryo
of a couple affected by recurrent pregnancy loss due to refractory CHI,
pregnancy outcomes are normalised. Although surrogacy is not universally
available or acceptable, it should therefore be considered an
alternative route to parenthood for these women.
Changing the maternal “host” appears to be highly effective in
preventing recurrent CHI. This observation reinforces the hypothesis
that CHI is driven by an abnormal maternal immune response against the
placenta.
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