CONCLUSIONS AND IMPLICATIONS
Human leukocyte migrates into inflamed tissues and secretes TNF-α and
IL-6. Thus, leukocyte plays an important role in inflammatory diseases.
recIAP inhibits TNF-α and IL-6 secreted by freshly extracted human
leukocyte in the absence of LPS. The results in this study indicate that
recIAP is a promising therapeutic candidate for diseases related to
leukocyte TNF-α and IL-6 secretion.