Endometrial Receptivity Analysis
The ERA (iGenomix, Valencia, Spain) is a transcriptomic analysis combined with artificial intelligence technology for dating the WOI19. The test assesses the expression of 238 genes that are biomarkers of endometrial dating. It has been hypothesized that the ERA can personalize the timing of ET, synchronizing embryonic development with the endometrial WOI of a given patient33.
The ERA was used to determine endometrial receptivity in a sample obtained seven days after the LH serum peak in a natural cycle or five days after progesterone administration in a hormone replacement cycle. Endometrial biopsies were collected from the uterine fundus, and samples were analyzed by iGenomix according to their protocol19,20,23,33. Endometria were classified by expression profile as receptive or pre- or post- receptive34.