Endometrial Receptivity Analysis
The ERA (iGenomix, Valencia, Spain) is a transcriptomic analysis
combined with artificial intelligence technology for dating the
WOI19. The test assesses the expression of 238 genes
that are biomarkers of endometrial dating. It has been hypothesized that
the ERA can personalize the timing of ET, synchronizing embryonic
development with the endometrial WOI of a given patient33.
The ERA was used to determine endometrial receptivity in a sample
obtained seven days after the LH serum peak in a natural cycle or five
days after progesterone administration in a hormone replacement cycle.
Endometrial biopsies were collected from the uterine fundus, and samples
were analyzed by iGenomix according to their
protocol19,20,23,33. Endometria were classified by
expression profile as receptive or pre- or post-
receptive34.