Methods

Study population

This study was conducted in theChildren’s Hospital of Chongqing Medical University (CHCMU). CHCMU is one of two National Clinical Research Center for Child Health and Disorders in China. The survey subjects are mainly medical and scientific professionals in the hospital. And the survey is voluntary.

Data collection

A survey that focuses on knowledge, utilization and demand of biobank was conducted online. We released an online questionnaire in July 2019. The respondents filled out the items as required and submit them online. Finally, a total of 182 valid questionnaires were collected.
The questionnaire contains 32 questions in total, thirty of them are multiple choice questions, and the other two are fill-in-the-blank questions. The questions were grouped into four parts: (1) Demographic information includes department, professional titles, education, administrator and age. (2) Knowledge of the hospital’s biobank which includes two parts. The first part is knowledge of biobank basic information, mainly including geographic location, management situation and WeChat public number of the biobank. The second part is knowledge of the special project of clinical sample resources, mainly including subsidy policy and sample warehousing process. Each part contains six questions, and each question has two answers: Yes and No. One score will be recorded when the answer is Yes, so the total score of each part is 6 scores, and the total score of all the two parts is 12 scores. (3) Status of utilization of the hospital’s biobank, mainly including is there a person responsible for the collection and processing of samples in your biological sample project, do the samples currently collected by yourself have quality assurance, do you regularly monitor the quality of your samples. (4) Demand for the hospital’s biobank, including willingness to pay to store samples in the hospital’s biobank, is it acceptable to cost more than 5000 yuan per year for sample storage.
At the same time, we collected some indicators that can reflect the development of clinical disciplines, including the participation situation of National Natural Science Foundation of China (NSFC) and the number of published English papers in different clinical disciplines in the past five years (2014-2018). NSFC is the most common national fund project in China, so it is included in this study.
In this study, clinical disciplines were divided into key disciplines and non-key disciplines. And key disciplines are determined according to the evaluation results of discipline construction of government departments.

Data analysis

SPSS 22.0 was used to complete data cleaning and analysis. Quantitative data was described by mean and standard deviation, and was analyzed by independent samples t test. But when the quantitative data did not conform to normal distribution, the rank sum test was used. Qualitative data was described by frequency and percentage, and was analyzed by chi-square test.