Prediction of epitopes of anti-properdin
Anti-Properdin epitopes were predicted using the IEBD server - http://tools.iedb.org/bcell/ (Fig. 4A). The majority of the binding epitopes were outside of the “vertex”, formed at the junction of two monomers and responsible for the convertase binding. They were located in the linker regions between different “vertexes”. The predicted peptide antigenic determinants of a molecule of prorperdin with a size greater than 3 amino acid residues are presented in Table 3.