Functions enriched within adaptive genomic regions
The mammalian phenotype terms showed some significant tests for
enrichment based on the overlap of annotated genes from the four
chromosome regions (Table S11). The top three terms with lowest P-value
from our list of 98 candidate genes on chromosome 01 (which is
associated with maturity) were abnormal social investigation, abnormal
blood urea nitrogen level, and induced hyperactivity. The three top
terms output for our list of 260 genes on chromosome 02 (which is
associated with body size traits) were short tibia, decreased brown fat
cell lipid droplet size, and Purkinje cell degeneration. The phenotypes
in fishes did not show significant Fisher’s exact tests for enrichment
of terms, although for chromosome 01, the top three ranked phenotypic
terms (based on combined score, Chen et al. 2013) may be relevant to the
associations we observed in this study. These terms were reproductive
behavior, response to absence of light, and entrainment of circadian
clock by photoperiod (Table S12).