Parameter
Estimate (RSE %)
Bootstrap analysis Estimate (95% CI)
Structural model parameters
Lag time (h) 0.32 (10.4) 0.32 (0.24-0.38)
Ka (h-1) 1.13 (10.3) 1.13 (0.89-1.47)
Vd (L) 140 (6.19) 140 (123-158)
CL (L/h) 14.7 (7.02) 14.7 (12.8-17.0)
Covariates
Height on Vd* 2.17 (33.0) 2.17 (0.39-3.82)
FGL on Vd* 0.32 (36.4) 0.31 (0.08-0.63)
eGFR on CL** 0.53 (29.2) 0.53 (0.08-0.88)
Interindividual variability (IIV)
Lag time 0.49 (16.4) 0.49 (0.21-0.78)
Ka 0.47 (17.4) 0.47 (0.23-0.67)
Vd 0.32 (14.1) 0.32 (0.20-0.40)
CL 0.37 (13.4) 0.37 (0.28-0.44)
Correlation between CL and Vd 0.82 (8.24) 0.82 (0.56-1.00)
Residual variability
Proportional (%) 0.18 (4.89) 0.18 (0.15-0.22)