Figure legends
Figure 1. Diagnostic plots for gabapentin pharmacokinetic final
model. (A) Observed vs. population and individual predicted GBP
concentrations. Linear regression fit is shown in black, whereas
identity line in grey. (B) Population and individual weighted residuals
(PWRES and IWRES, respectively) vs. time (upper panels; left) andvs. predictive GBP concentrations (lower panels; left);
Normalized and prediction distribution error (NPDE) vs. time and
GBP concentrations for the final model (right). The observed data are
presented as black circles. (C) Visual predictive check (VPC) plot for
the final model. The observed data are presented as black circles. The
dashed lines represent the 5th, 50thand 95th percentiles of the predicted data. The grey
areas represent the 95% confidence interval of predicted percentiles.