Conclusion
This systematic review and meta-analysis summarized the available data on the review question and identified an optimal protocol for FSE. With short sectioning intervals perpendicular to the long axis of SLN (L-protocol), FSE will yield high sensitivity in detecting metastases, which allows for a precise intraoperative pathological assessment of SLNs. This finding may redefine the role of FSE in SLNB and should be considered in future practice of this technique.