Goal of the study
Primary endpoints were operative mortality, NE and need of renal replacement therapy (RRT). Secondary endpoints were time to extubation, need of tracheostomy and intensive care unit (ICU) length of stay (LOS). Operative mortality included 30 day or in-hospital mortality. NEs included stroke (defined as a cerebrovascular accident confirmed by radiologic imaging, computed tomography or magnetic resonance imaging) and seizures, localized or generalized, with or without positive radiologic imaging. According the clinical outcome, NEs were classified as temporary (TNEs) or permanent neurologic deficits (PNDs). The effect of temperature on lower body protection was evaluated by acute kidney injury (AKI) necessitating RRT. Changes in kidney function were also analysed according the KIDGO criteria3. Primary endpoints were analysed separately, grouped as death and PND or as composite endpoint (death, PND and need of RRT).
Results were reported for the whole statistics and were compared as well between the two groups.