Conclusion
A 52-year-old man with no history of mental disorder and multiple medical comorbidities presented following exposure to a COVID-19 patient; his test result was shown to be positive and soon started to develop symptoms of fever, cough and shortness of breath. His course of an illness complicated further after he developed headache and confusion after he was transferred to the intensive care unit; his mental state was shown to be abnormally ranging from cognitive deficit initially to grandiosity, lack of sleep, talkativeness and persecutory beliefs with an intact cognitive function, later he was admitted to a psychiatric facility under the impression of a manic episode, His laboratory results were evident for increased inflammatory markers praising severe infection, neuroimaging was only positive for subtle white matter changes, he was treated with antipsychotics and mood-stabilizing agent until reached partial remission.