Data and Statistical Analysis
Data was analysed with SPSS Version 26 software. Continuous variables
were expressed as mean ± standard deviation and categorical variables
were summarised as frequencies and percentages. Normality of all
continuous variables was tested with the Kolmogorov-Smirnov test. Since
the variables were not normally distributed, the Wilcoxon signed rank
test was used to compare the mean in all ECG parameters while the
Mann-Whitney U test was used to compare the changes in ECG parameters
between gender and donepezil doses. We performed point-biserial
correlations to assess whether cardiac comorbidities and concurrent use
of medications alongside donepezil were associated with changes in ECG
parameters. The Kruskal Wallis test was used to evaluate whether any
changes in ECG parameters were associated with duration of donepezil
treatment. Statistical significance was defined as P-value
<0.05. Our data and statistical analysis are compliant with
the recommendations on experimental design and analysis in pharmacology
(Curtis & Alexander et al., 2018).