Data and Statistical Analysis
Data was analysed with SPSS Version 26 software. Continuous variables were expressed as mean ± standard deviation and categorical variables were summarised as frequencies and percentages. Normality of all continuous variables was tested with the Kolmogorov-Smirnov test. Since the variables were not normally distributed, the Wilcoxon signed rank test was used to compare the mean in all ECG parameters while the Mann-Whitney U test was used to compare the changes in ECG parameters between gender and donepezil doses. We performed point-biserial correlations to assess whether cardiac comorbidities and concurrent use of medications alongside donepezil were associated with changes in ECG parameters. The Kruskal Wallis test was used to evaluate whether any changes in ECG parameters were associated with duration of donepezil treatment. Statistical significance was defined as P-value <0.05. Our data and statistical analysis are compliant with the recommendations on experimental design and analysis in pharmacology (Curtis & Alexander et al., 2018).