Key Results:
Donepezil significantly prolonged the PR (P=0.04), QRS (P=0.04) and QT
(P=0.002) intervals. The increase in QT intervals remained significant
on correction for heart rate; resulting in 8 (13.6%) patients
developing high arrhythmogenic risk based on assessment using QT
nomogram plots. Concomitant use of tricyclic antidepressants was
associated with significant QT prolongation, while use of rate limiting
calcium channel blockers was associated with significant PR
prolongation, and beta-blockers with reduction in heart rate.