Conclusion and Implications:
Our results clearly demonstrate that long-term use of donepezil results in prolongation of the QT interval. We suggest ECG evaluation should take place before and after donepezil initiation, and clinicians should be even more vigilant in those prescribed tricyclic antidepressants.
Keywords: Cardiac pharmacology, pharmacodynamics, ageing/aging, donepezil, electrocardiography, cardiac arrhythmias, cholinesterase inhibitors