Hypersensitivity reactions
Rare cases of pruritus, urticaria, angioedema and anaphylaxis were
reported (161-163). The possible mechanisms can be both immunologic and
non-immunologic, which seems to depend on the administration route and
formulation (161). In some cases, DHRs have been attributed to the
additives such as Castor oil
(162),
or Cremophor EL
(163).
SPTs and IDTs or basophil activation test (BAT) can be used for the
diagnosis of cyclosporine- and additive-induced IgE-mediated IHRs
(18,161,163).