Legend to Figures
Figure 1. Dot and box plot (median and 95% CI) of sputum cell
PAPPA mRNA expression scores in: (A) never-smoking severe asthma (NSA),
smoking and ex-smoking SA (SSA), mild-moderate asthma (MMA) and healthy
controls (HC); (B) in eosinophilic, neutrophilic, mixed and
pauci-granulocytic inflammation in asthmatics and healthy controls (HC);
and (C) in the transcriptomic-associated clusters (TAC1, TAC2 and TAC3)
in U-BIOPRED. Sputum PAPPA protein levels in NSA, SSA, MMA and HC
subjects (D); eosinophilic, neutrophilic, mixed and pauci airway
inflammation subjects and HC (E); in T2-high and T2-low asthmatic
subjects and HC subjects (F).
Figure 2. Receiver operating characteristic (ROC) curves
analysis of the sensitivity and specificity of serum (A) and sputum (B)
PAPPA levels for sputum eosinophilic airway inflammation (sputum
eosinophils >1.49%) in asthmatic subjects. AUC, Area under
the curve.