Results
Table S1 summarises the clinical and physiological characteristics and Tables S2 and S3 the asthma participants according to granulocytic inflammation status and to molecular phenotype, respectively. Using MetaPhlAn2, out of 193 sputum samples, 189 were available for species-level analysis. Although 46 sputum samples were analysed at follow-up, there were paired samples for baseline and longitudinal analyses in only 33 subjects. We also analysed the results in terms of the granulocytic inflammation defined by the level of sputum eosinophils and neutrophils (16) (Table S2 ) and of the molecular phenotypes defined as transcriptomic-associated clusters (TACs) (Table S3 ) (14). The molecular pathways characterising the 3 TACs is shown in Table S4 .