Contributors
IMA, PJS & KFC conceived the idea; IMA, KFC, PJS & RD obtained the
funding for U-BIOPRED project; SB, JR, PH obtained the funding for the
metagenomic analysis; SB, JR, PH, IMA, SHC, AV & KFC discussed the
approach to data analysis; .AV, FXI, MIA, NZK analysed the data; AV, FXI
& KFC wrote the manuscript; all authors contributed to its finalisation
and agreed with the final version for submission.
All authors gave final approval of the manuscript, had full access to
all the data in the study, and had final responsibility for the decision
to submit for publication.
Declaration of interests
Dr Chotirmall has received lecture fees from Astra-Zeneca, serves on
advisory boards for Boehringer-Ingelheim, CSL Behring and Pneumagen Ltd.
and is on Data and Safety Monitoring Boards (DSMB) for Inovio
Pharmaceuticals and Imam Abdulrahman Bin Faisal University all outside
of the submitted work. Dr Maitland-van der Zee has received grants from
Health Holland and she is the PI of a P4O2 (Precision Medicine for more
Oxygen) public private partnership sponsored by Health Holland involving
many private partners that contribute in cash and/or in kind (Boehringer
Ingelheim, Breathomix, Fluidda, Ortec Logiqcare, Philips, Quantib-U,
Smartfish, SODAQ, Thirona, TopMD and Novartis), received unrestricted
research grants from GSK, Boehringer Ingelheim and Vertex, received
consulting fees paid to her institution from Boehringer Ingelheim and
AstraZeneca, and received honoraria for lectures paid to her institution
from GlaxoSmithKline; outside the submitted work. Dr. Dahlén reports
personal fees from AZ, Cayman Chemicals, GSK, Novartis, Regeneron,
Sanofi, TEVA, outside the submitted work. Dr Baribaud owns stock options
from his former and current employer. Dr Sterk is scientific advisor and
has an officially non-substantial share in the SME Breathomix that
produces eNoses. Dr Chung has received honoraria for participating in
Advisory Board meetings of Roche, Merck, Shionogi and Rickett-Beckinson
and has also been renumerated for speaking engagements for Novartis and
AZ. Dr Riley worked for and had shares in GSK. Dr. Bates reports to be
an employee of Johnson & Johnson and to have previously worked and
holds stock in GSK. Dr Djukanovic declares consulting fees from
Synairgen, Sanofi and Galapagos, lecture fees from GSK, AZ and Airways
Vista and he holds shares from Synairgen. Dr Howarth is an employee of
GSK. Dr Montuschi, Dr Kermani, Dr Adcock, Dr Ivan, Dr Abdel-Aziz and Mr
Versi have nothing to declare.