Results
Table S1 summarises the clinical and physiological
characteristics and Tables S2 and S3 the asthma
participants according to granulocytic inflammation status and to
molecular phenotype, respectively. Using MetaPhlAn2, out of 193 sputum
samples, 189 were available for species-level analysis. Although 46
sputum samples were analysed at follow-up, there were paired samples for
baseline and longitudinal analyses in only 33 subjects. We also analysed
the results in terms of the granulocytic inflammation defined by the
level of sputum eosinophils and neutrophils (16) (Table S2 ) and
of the molecular phenotypes defined as transcriptomic-associated
clusters (TACs) (Table S3 ) (14). The molecular pathways
characterising the 3 TACs is shown in Table S4 .