H
influenzae & M catarrhalis in sputum of severe asthma with
inflammasome and neutrophil activation
Ali Versi1*, Fransiskus Xaverius
Ivan2*, Mahmoud I Abdel-Aziz3,
Stewart Bates4, John Riley4,
Frederic Baribaud5,
Nazanin Zounemat
Kermani1, Paolo Montuschi6,
Sven-Erik Dahlen7, Ratko
Djukanovic8, Peter Sterk3,
Anke-Hilse Maitland-Van Der Zee3, Sanjay H
Chotirmall2, 9, Peter Howarth8, Ian
M Adcock1, Kian Fan Chung1, on
behalf of U-BIOPRED consortium.
1National Heart & Lung Institute & Data Science
Institute, Imperial College London, United Kingdom;2Lee Kong Chian School of Medicine, Nanyang
Technological University, Singapore, Singapore;3Amsterdam University Medical Centers, Department of
Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands;4Respiratory Therapeutic Unit, GSK, Stockley Park, UK;5Janssen Research and Development, High Wycombe,
Buckinghamshire, United Kingdom; 6Department of
Pharmacology, Catholic University of the Sacred Heart, Rome, Italy;7Centre for Allergy Research, Karolinska Institute,
Stockholm, Sweden; 8Faculty of Medicine, Southampton
University, Southampton, UK and NIHR Southampton Respiratory Biomedical
Research Unit, University Hospital Southampton, Southampton, UK;9Department of Respiratory and Critical Care Medicine,
Tan Tock Seng Hospital, Singapore.
*Equal contribution
Running title : H influenzae and M catarrhalis in
severe asthma