COVID-19: ACE2 binding and insulin resistance.
The angiotensin-converting enzyme 2 (ACE-2) is part of the dual system,
the renin-angiotensin-system (RAS), and includes the
ACE-Angiotensin-II-AT1R axis. AT1R is
involved in most Angiotensin II effects, including oxidative stress
generation, pro-inflammatory and pro-fibrotic effects in the respiratory
system as well as insulin resistance. 10,11 SARS-CoV-2
binds 12 and downregulates ACE-2, enhancing the
AT1R axis 13. It is likely to be
associated with insulin resistance. 14