Data source and searches
Electronic algorithms in combination with controlled vocabulary and search terms were used to identify relevant randomised controlled trials (RCTs) and economic evaluations in: i) MEDLINE (via PubMed, February 2020); ii) Cochrane Controlled Trials Register (via The Cochrane Library, February 2020), and; iii) EMBASE (via Ovid, February 2020). Search algorithms were adapted to the requirements of each database, and validated filters were used to retrieve appropriate designs (tables S1 and S2). Additional studies provided by the GDG and previous SR were also evaluated (figure 1A and 1B).