Quantifications and statistical analyses
Statistical analysis was applied in presence of at least n = 3 biologic replicates, and only descriptive statistics are reported. Data were expressed as mean ± SD, where one-tailed nonparametric Mann-Whitney test was performed to compare two independent groups. In all the analyses, the significance threshold was set at 0.05. Differences were considered statistically significant at *p<0.05. Analyses were performed using GraphPad Prism v8.4.1 (GraphPad Software, San Diego, CA).