Quantifications and statistical analyses
Statistical analysis was applied in presence of at least n = 3 biologic
replicates, and only descriptive statistics are reported. Data were
expressed as mean ± SD, where one-tailed nonparametric Mann-Whitney test
was performed to compare two independent groups. In all the analyses,
the significance threshold was set at 0.05. Differences were considered
statistically significant at *p<0.05. Analyses were performed
using GraphPad Prism v8.4.1 (GraphPad Software, San Diego, CA).