THE LAST TEN YEARS OF THE RANDOMIZED STUDIES

General clinical data of the literary findings analyzed

Physiological dose
to 0.3 mg
SIGNIFICANCE: 39.6% of American adults and 18.5% of young people are obese. Brazil ranks fifth in the world ranking, with about 18 million people. In this scenario, melatonin has evidenced an important function in the regulation of energy metabolism. INFORMATION GAP: What is the real influence of melatonin supplementation on obesity control ? OBJECTIVE: A systematic review followed by a meta-analysis of randomized clinical trials over the past ten years to explore the efficacy and safety of melatonin for weight reduction and improves of metabolic disorder.METHODS: The PRISMA rules and COCHRANE INSTRUMENT were followed. The descriptors melatonin, obesity, metabolism, weight loss andclinical trial were used.RESULTS: 1. The results (n = 51) were significant that the imbalance of melatonin can lead to metabolic disorders and circadian rhythmic disorders, p <0.05 (R2 = 94.5%).
  1. Also, the studies showed improvement in metabolic disorder, glucose homeostasis, weight loss (> 3.0 kg/month), reduced inflammatory process and improved sleep after supplementation with or without associated drug melatonin.
  2. However, it is not yet known the best concentration to be used in humans, especially in the long-term.
CONCLUSION: Melatonin is important for energy regulation and weight loss, but further studies of its supplementation in the control of obesity are needed.REFERENCES
DOSE
Long-term