Microarray data analysis
For the microarray datasets (GSE17400, GSE19580), the data was analysed using the online Geo2R tool (default options) to determine the differential expression of genes between control and the target set and the output file containing a list of differentially expressed genes was downloaded. Amongst these genes, only those whose regulation was significant (adj. p<=0.05) were uploaded in the NetworkAnalyst software and downstream analysis was done in an identical manner to that in the RNA-seq data analysis.