Pathway Total Expected Expected Hits Hits P.Value FDR
TNF signaling pathway 110 42.9 80 80 5.09E-13 5.09E-13 1.62E-10 1.62E-10
Non-alcoholic fatty liver disease (NAFLD) 149 58.1 99 99 7.23E-12 7.23E-12 1.15E-09 1.15E-09
Metabolic pathways 1430 558 670 670 1.40E-11 1.40E-11 1.49E-09 1.49E-09
Herpes simplex infection 492 192 261 261 4.63E-11 4.63E-11 3.68E-09 3.68E-09
Pancreatic cancer 75 29.2 57 57 6.33E-11 6.33E-11 4.02E-09 4.02E-09
HTLV-I infection 219 85.4 130 130 5.07E-10 5.07E-10 2.69E-08 2.69E-08
Hepatitis C 155 60.4 98 98 6.30E-10 6.30E-10 2.86E-08 2.86E-08
Epstein-Barr virus infection 201 78.4 120 120 1.46E-09 1.46E-09 5.80E-08 5.80E-08
Cell cycle 124 48.3 81 81 2.06E-09 2.06E-09 7.28E-08 7.28E-08
Colorectal cancer 86 33.5 60 60 6.08E-09 6.08E-09 1.93E-07 1.93E-07
DNA replication 36 14 31 31 6.79E-09 6.79E-09 1.96E-07 1.96E-07
Hepatitis B 163 63.5 98 98 2.87E-08 2.87E-08 7.60E-07 7.60E-07
Apoptosis 136 53 84 84 5.10E-08 5.10E-08 1.25E-06 1.25E-06
Chronic myeloid leukemia 76 29.6 52 52 1.73E-07 1.73E-07 3.92E-06 3.92E-06
Influenza A 167 65.1 96 96 7.79E-07 7.79E-07 1.65E-05 1.65E-05
Huntington’s disease 193 75.2 108 108 1.00E-06 1.00E-06 1.99E-05 1.99E-05
Small cell lung cancer 93 36.3 59 59 1.40E-06 1.40E-06 2.54E-05 2.54E-05
Prostate cancer 97 37.8 61 61 1.44E-06 1.44E-06 2.54E-05 2.54E-05
Parkinson’s disease 142 55.4 83 83 1.72E-06 1.72E-06 2.87E-05 2.87E-05
AGE-RAGE signaling pathway in diabetic complications 100 39 62 62 2.38E-06 2.38E-06 3.78E-05 3.78E-05
Endometrial cancer 58 22.6 40 40 3.38E-06 3.38E-06 5.12E-05 5.12E-05
Non-small cell lung cancer 66 25.7 44 44 4.53E-06 4.53E-06 6.55E-05 6.55E-05
Kaposi’s sarcoma-associated herpesvirus infection 186 72.5 102 102 6.78E-06 6.78E-06 9.37E-05 9.37E-05
Measles 138 53.8 79 79 9.06E-06 9.06E-06 0.000116 0.000116
Platinum drug resistance 73 28.5 47 47 9.16E-06 9.16E-06 0.000116 0.000116
Alzheimer’s disease 171 66.7 94 94 1.35E-05 1.35E-05 0.000166 0.000166
Endocrine resistance 98 38.2 59 59 1.55E-05 1.55E-05 0.000182 0.000182
Pathways in cancer 530 207 252 252 2.01E-05 2.01E-05 0.000229 0.000229
Glioma 75 29.2 47 47 2.62E-05 2.62E-05 0.000287 0.000287
Valine, leucine and isoleucine degradation 48 18.7 33 33 2.71E-05 2.71E-05 0.000288 0.000288
Tuberculosis 179 69.8 96 96 4.15E-05 4.15E-05 0.000425 0.000425
Ubiquitin mediated proteolysis 137 53.4 76 76 5.89E-05 5.89E-05 0.000585 0.000585
Oxidative phosphorylation 133 51.8 74 74 6.44E-05 6.44E-05 0.00062 0.00062
Base excision repair 33 12.9 24 24 8.52E-05 8.52E-05 0.000797 0.000797
Endocytosis 244 95.1 124 124 9.11E-05 9.11E-05 0.000828 0.000828
Autophagy - animal 128 49.9 71 71 0.000102 0.000102 0.000905 0.000905
p53 signaling pathway 72 28.1 44 44 0.000112 0.000112 0.000963 0.000963
Glyoxylate and dicarboxylate metabolism 30 11.7 22 22 0.000139 0.000139 0.00116 0.00116
Mismatch repair 23 8.97 18 18 0.000143 0.000143 0.00117 0.00117
EGFR tyrosine kinase inhibitor resistance 79 30.8 47 47 0.000167 0.000167 0.00132 0.00132
Neurotrophinsignaling pathway 119 46.4 66 66 0.000178 0.000178 0.00132 0.00132
Legionellosis 55 21.4 35 35 0.000179 0.000179 0.00132 0.00132
B cell receptor signaling pathway 71 27.7 43 43 0.000179 0.000179 0.00132 0.00132
FoxOsignaling pathway 132 51.5 72 72 0.000186 0.000186 0.00134 0.00134
NOD-like receptor signaling pathway 178 69.4 93 93 0.000193 0.000193 0.00136 0.00136
Fluid shear stress and atherosclerosis 139 54.2 75 75 0.000217 0.000217 0.0015 0.0015
Chagas disease (American trypanosomiasis) 103 40.2 58 58 0.000252 0.000252 0.0017 0.0017
Progesterone-mediated oocyte maturation 99 38.6 56 56 0.000273 0.000273 0.00181 0.00181
IL-17 signaling pathway 93 36.3 53 53 0.000306 0.000306 0.00199 0.00199
ErbBsignaling pathway 85 33.1 49 49 0.000354 0.000354 0.00225 0.00225
Protein processing in endoplasmic reticulum 165 64.3 86 86 0.000368 0.000368 0.00229 0.00229
HIF-1 signaling pathway 100 39 56 56 0.000387 0.000387 0.00237 0.00237
Mitophagy - animal 65 25.3 39 39 0.000463 0.000463 0.00273 0.00273
Central carbon metabolism in cancer 65 25.3 39 39 0.000463 0.000463 0.00273 0.00273
Carbon metabolism 116 45.2 63 63 0.000535 0.000535 0.0031 0.0031
Pertussis 76 29.6 44 44 0.000614 0.000614 0.00349 0.00349
Prolactin signaling pathway 70 27.3 41 41 0.000673 0.000673 0.00376 0.00376
Osteoclast differentiation 128 49.9 68 68 0.000745 0.000745 0.00408 0.00408
Toxoplasmosis 113 44 61 61 0.000802 0.000802 0.00432 0.00432
mTORsignaling pathway 153 59.6 79 79 0.000903 0.000903 0.00479 0.00479
Nucleotide excision repair 47 18.3 29 29 0.00131 0.00131 0.00674 0.00674
Proteasome 45 17.5 28 28 0.00131 0.00131 0.00674 0.00674
Melanoma 72 28.1 41 41 0.00146 0.00146 0.00735 0.00735
NF-kappa B signaling pathway 100 39 54 54 0.00155 0.00155 0.00769 0.00769
Epithelial cell signaling in Helicobacter pylori infection 68 26.5 39 39 0.00157 0.00157 0.00769 0.00769
Acute myeloid leukemia 66 25.7 38 38 0.00163 0.00163 0.00785 0.00785
Viral carcinogenesis 201 78.4 99 99 0.00173 0.00173 0.00823 0.00823
Breast cancer 147 57.3 75 75 0.00184 0.00184 0.00863 0.00863
Citrate cycle (TCA cycle) 30 11.7 20 20 0.00195 0.00195 0.00897 0.00897
Vibrio cholerae infection 50 19.5 30 30 0.00205 0.00205 0.00923 0.00923
Lysosome 123 47.9 64 64 0.00209 0.00209 0.00923 0.00923
Notch signaling pathway 48 18.7 29 29 0.00209 0.00209 0.00923 0.00923
Hippo signaling pathway 154 60 77 77 0.00326 0.00326 0.0142 0.0142
Tight junction 170 66.3 84 84 0.00333 0.00333 0.0143 0.0143
Bladder cancer 41 16 25 25 0.00351 0.00351 0.0147 0.0147
Apoptosis - multiple species 33 12.9 21 21 0.00354 0.00354 0.0147 0.0147
Thyroid cancer 37 14.4 23 23 0.00357 0.00357 0.0147 0.0147
Longevity regulating pathway - multiple species 62 24.2 35 35 0.00384 0.00384 0.0157 0.0157
Biosynthesis of amino acids 75 29.2 41 41 0.00407 0.00407 0.0164 0.0164
Renal cell carcinoma 69 26.9 38 38 0.00472 0.00472 0.0186 0.0186
Toll-like receptor signaling pathway 104 40.5 54 54 0.00475 0.00475 0.0186 0.0186
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 20 7.8 14 14 0.00487 0.00487 0.0189 0.0189
Estrogensignaling pathway 138 53.8 69 69 0.00518 0.00518 0.0198 0.0198
Terpenoid backbone biosynthesis 22 8.58 15 15 0.00525 0.00525 0.0199 0.0199
Glycine, serine and threonine metabolism 40 15.6 24 24 0.00562 0.00562 0.021 0.021
Spliceosome 134 52.2 67 67 0.00581 0.00581 0.0214 0.0214
Oocyte meiosis 125 48.7 63 63 0.00586 0.00586 0.0214 0.0214
VEGF signaling pathway 59 23 33 33 0.00598 0.00598 0.0216 0.0216
Adherens junction 72 28.1 39 39 0.00617 0.00617 0.022 0.022
Pyrimidine metabolism 57 22.2 32 32 0.00626 0.00626 0.0221 0.0221
Proteoglycans in cancer 201 78.4 96 96 0.00636 0.00636 0.0222 0.0222
Pathogenic Escherichia coli infection 55 21.4 31 31 0.00654 0.00654 0.0226 0.0226
MAPK signaling pathway 295 115 136 136 0.0066 0.0066 0.0226 0.0226
Fatty acid metabolism 53 20.7 30 30 0.00683 0.00683 0.0231 0.0231
Fc gamma R-mediated phagocytosis 91 35.5 47 47 0.00917 0.00917 0.0307 0.0307
N-Glycan biosynthesis 50 19.5 28 28 0.0107 0.0107 0.0354 0.0354
Cellular senescence 160 62.4 77 77 0.0109 0.0109 0.0356 0.0356
Fatty acid degradation 44 17.2 25 25 0.0122 0.0122 0.0397 0.0397
Glycolysis / Gluconeogenesis 68 26.5 36 36 0.0132 0.0132 0.0419 0.0419
Fc epsilon RI signaling pathway 68 26.5 36 36 0.0132 0.0132 0.0419 0.0419
Alanine, aspartate and glutamate metabolism 36 14 21 21 0.0144 0.0144 0.0452 0.0452
Signaling pathways regulating pluripotency of stem cells 139 54.2 67 67 0.016 0.016 0.0498 0.0498
2-Oxocarboxylic acid metabolism 18 7.02 12 12 0.0161 0.0161 0.0498 0.0498
One carbon pool by folate 20 7.8 13 13 0.0165 0.0165 0.0505 0.0505
Pyruvate metabolism 39 15.2 22 22 0.0202 0.0202 0.0613 0.0613
Amino sugar and nucleotide sugar metabolism 48 18.7 26 26 0.0231 0.0231 0.0693 0.0693
Antifolate resistance 31 12.1 18 18 0.0241 0.0241 0.0717 0.0717
GnRHsignaling pathway 93 36.3 46 46 0.0249 0.0249 0.0734 0.0734
Wntsignaling pathway 158 61.6 74 74 0.0256 0.0256 0.0745 0.0745
Insulin signaling pathway 137 53.4 65 65 0.0258 0.0258 0.0745 0.0745
Regulation of lipolysis in adipocytes 55 21.4 29 29 0.0262 0.0262 0.0751 0.0751
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 25 9.75 15 15 0.0268 0.0268 0.0761 0.0761
Tryptophan metabolism 42 16.4 23 23 0.0272 0.0272 0.0766 0.0766
Protein export 23 8.97 14 14 0.0275 0.0275 0.0768 0.0768
Longevity regulating pathway 89 34.7 44 44 0.0281 0.0281 0.0778 0.0778
Steroid biosynthesis 19 7.41 12 12 0.0284 0.0284 0.0778 0.0778
Sphingolipid signaling pathway 119 46.4 57 57 0.0286 0.0286 0.0778 0.0778
Insulin resistance 108 42.1 52 52 0.0319 0.0319 0.0859 0.0859
Peroxisome 83 32.4 41 41 0.0337 0.0337 0.0902 0.0902
Inositol phosphate metabolism 74 28.8 37 37 0.0345 0.0345 0.0915 0.0915