Introduction
As a result of imperfect immune function, children are naturally
susceptible to various respiratory viruses and not easy to spontaneously
resolve.Since the outbreak of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection began in Wuhan city,Hubei province,
China.1-2 more than 2,000
pediatric cases have been reported
nationwide in just over two months.3 Recently, an
increasing number of coronavirus disease 2019 (COVID-19) patients were
discharged from the hospital and received regular follow-up
and observation.
Re-detectable
positive (RP) of
SARS-CoV-2 RNA test in some
recovered patients has been reported.4 Our hospital
also reported that 38 of the 262 cured and discharged patients were
found to be RP during the convalescence. Among them, patients younger
than 14 years old were more common compared with those between the ages
of 14 and 60 years.5 In the long-term follow-up,we
also observed that a large proportion of pediatric patients were RP
(nasopharyngeal swabs and/or anal swabs) after discharge,even repeated
RP and several readmission, asymptoms or with mild symptoms, and chest
computed tomography (CT) showed sustained remission of pulmonary
lesions.Obviously,RP means that the virus has not been completely
cleared.There is still some uncertainty about whether such patients are
infectious,but it undoubtedly has a serious impact on the formulation
and implementation of prevention and control measures.
Despite great advances in rapid detection, diagnosis and treatment
in SARS-CoV-2 infection, little is
known about the
early
risk factors for RP.In particular, data on convalescent children as a
special population have not been reported.We aimed to identify
the early risk factors for RP, and
to provide a basis for early clinical prediction and risk
stratification.