Conclusion:
To our knowledge, this is the first study to demonstrate clear recovery
of untwist and twist mechanics, global longitudinal strain and LV
ejection fraction in HFrEF patients under eleven months therapy of
Sacubitril/Valsartan that effect which might be explained by a state of
chronic deloading with reduction of LV end diastolic pressure which
consequently helps in restoration of starling’s forces with recovery of
LV geometry that lead finally to the improvement of myocardial
performance.
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