Exclusion Criteria:
- Pregnant or nursing women.
- History of hypersensitivity to any of the study drugs.
- History of angioedema drug related or otherwise.
- Subjects with a heart transplant or ventricular assistance device
(VAD) or intent to transplant (on transplant list) or implant a VAD.
- Subjects with a cardio resynchronization therapy device (CRT/CRT-D)
implanted within 6 months of screening visit.
- Subjects who were currently taking inotropic agents.
- Bile acid sequestering agents such as cholestyramine or colestipol
were prohibited to avoid interference with study drug absorption.
- Any hospital admission/discharge related to heart failure within 2
weeks prior to baseline.
- The use of outpatient or inpatient i.v. diuretic therapy within 2
weeks prior to baseline.
- Potassium > 5.2 mEq/L at screening.