Conclusion:
To our knowledge, this is the first study to demonstrate clear recovery of untwist and twist mechanics, global longitudinal strain and LV ejection fraction in HFrEF patients under eleven months therapy of Sacubitril/Valsartan that effect which might be explained by a state of chronic deloading with reduction of LV end diastolic pressure which consequently helps in restoration of starling’s forces with recovery of LV geometry that lead finally to the improvement of myocardial performance.
References :
  1. Zaca V, Ballo P, Galderisi M, Mondillo S. Echocardiography in the assessment of left ventricular longitudinal systolic function: current methodology and clinical applications. Heart Fail Rev. 2010; 15:23–37.
  2. Cameli M, Mondillo S, Solari M, Righini FM, Andrei V, Contaldi C, et al. Echocardiographic assessment of left ventricular systolic function: from ejection fraction to torsion. Heart Fail Rev. 2016; 21:77–94.
  3. Torrent-Guasp F, Ballester M, Buckberg GD, Carreras F, Flotats A, Carriò I, et al. Spatial orientation of the ventricular muscle band: physiologic contribution and surgical implications. J Thorac Cardiovasc Surg. 2001; 122:389–392.
  4. Buckberg G, Hoffman JIE, Mahajan A, Saleh S, Coghlan C. Cardiac mechanics revisited. Circulation. 2008; 118:2571–2587.
  5. Carreras F, García-Barnes J, Gil D, Pujadas S, Li Chi H, Suarez-Arias R, et al. Left ventricular torsion and longitudinal shortening: two fundamental components of myocardial mechanics assessed by tagged cine-MRI in normal subjects. Int J Cardiovasc Imaging. 2012; 28:273–284.
  6. Mondillo S, Galderisi M, Mele D, Cameli M, Lomoriello VS, Zaca V, et al. Echocardiography study group of the Italian society of C. Speckle tracking echocardiography: a new technique for assessing myocardial function. J Ultrasound Med. 2011; 30:71–83.
  7. Van Dalen BM, Soliman OI, Vletter WB, Kauer F, van der Zwaan HB, ten Cate FJ, Geleijnse ML. Feasibility and reproducibility of left ventricular rotation parameters measured by speckle tracking echocardiography. Eur J Echocardiogr. 2009; 10:669–676.
  8. Leitman M, Lysyansky P, Sidenko S, Shir V, Peleg E, Binenbaum M, Kaluski E, Krakover R, Vered Z. Two-dimensional strain a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr. 2004; 17:1021–1029.
  9. Teske AJ, De Boeck BW, Melman PG, Sieswerda GT, Doevendans PA, Cramer MJ. Echocardiographic quantification of myocardial function using tissue deformation imaging, a guide to image acquisition and analysis using tissue Doppler and speckle tracking. Cardiovasc Ultrasound. 2007; 5:27.
  10. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantification in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978; 58:1072–83.
  11. Lester SJ, Ryan EW, Schiller NB, Foster E. Best method in clinical practice and research studies to determine left atrial size. Am J Cardiol 1999; 84:829–32.
  12. Schiller N, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H et al. Recommendations for quantification of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography Subcommittee on Standards. J Am Soc Echocardiogr 1989; 2:358–68.
  13. Nagueh S, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smisteh OA et al. Recommandations of the evaluation of diastolic dysfunctions by echocardiography. J Am Soc Echocardiogr 2009; 22:108–28.
  14. Hollekim-Strand SM, Hoydahl SF, Follestad T, Dalen H, Bjørgaas MR,Wisløff U, et al. Exercise training normalizes timing of left ventricular untwist rate, but not peak untwist rate, in individuals with type 2 diabetes and diastolic dysfunction: a pilot study. J Am Soc Echocardiogr 2016; 29:421–430.
  15. Kumler T, Gislason GH, Kober L, Torp-Pedersen C. Persistence of the prognostic importance of left ventricular systolic function and heart failure after myocardial infarction: 17-year follow-up of the TRACE register. Eur J Heart Fail 2010; 12:805-11.
  16. Joyce E, Hoogslag GE, Leong DP, et al. Association between left ventricular global longitudinal strain and adverse left ventricular dilatation after ST-segment-elevation myocardial infarction. Circ Cardiovasc Imaging 2014; 7:74-81.
  17. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016; 37:2129-200.
  18. Lee JH, Kim MS, Kim EJ, et al. KSHF guidelines for the management of acute heart failure: part I. definition, epidemiology and diagnosis of acute heart failure. Korean Circ J 2019; 49:1-21.
  19. Yancy CW, Jessup M, Bozkurt B, et al. 2016 ACC/AHA/HFSA focused update on new pharmacological therapy for heart failure: an update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Failure Society of America. J Am Coll Cardiol 2016; 68:1476-88.
  20. Baumgartner H, Falk V, Bax JJ, et al. 2017 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J 2017; 38:2739-91.
  21. Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/ American Heart Association task force on clinical practice guidelines. Circulation 2017; 135:e1159-95.
  22. Lee JY, Sunwoo JS, Kwon KY, et al. Left ventricular ejection fraction predicts poststroke cardiovascular events and mortality in patients without atrial fibrillation and coronary heart disease. Korean Circ J 2018; 48:1148-56.
  23. Otterstad JE, Froeland G, St John Sutton M, Holme I. Accuracy and reproducibility of biplane two dimensional echocardiographic measurements of left ventricular dimensions and function. Eur Heart J 1997; 18:507-13.
  24. Smiseth OA, Torp H, Opdahl A, Haugaa KH, Urheim S. Myocardial strain imaging: how useful is it in clinical decision making? Eur Heart J 2016; 37:1196-207.
  25. Haddad F, Hunt SA, Rosenthal DN, Murphy DJ. Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation 2008; 117:1436-48.
  26. Keramida K, Farmakis D, Bingcang J, et al. Longitudinal changes of right ventricular deformation mechanics during trastuzumab therapy in breast cancer patients. Eur J Heart Fail 2019; 21:529-35.
  27. Negishi K, Negishi T, Haluska BA, Hare JL, Plana JC, Marwick TH. Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection. Eur Heart J Cardiovasc Imaging 2014; 15:324-31.
  28. Phelan D, Thavendiranathan P, Popovic Z, et al. Application of a parametric display of two-dimensional speckle-tracking longitudinal strain to improve the etiologic diagnosis of mild to moderate left ventricular hypertrophy. J Am Soc Echocardiogr 2014; 27:888-95.
  29. Negishi K, Negishi T, Hare JL, Haluska BA, Plana JC, Marwick TH. Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity. J Am Soc Echocardiogr 2013; 26:493-8.
  30. Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015; 28:1-39.e14.
  31. Vasan RS, Larson MG, Benjamin EJ, Evans JC and Levy D. Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med 1997; 336: 1350-1355.
  32. Wong M, Johnson G, Shabetai R, Hughes V, Bhat G, Lopez B and Cohn JN. Echocardiographic variables as prognostic indicators and therapeutic monitors in chronic congestive heart failure. Veterans Affairs cooperative studies V-HeFT I and II. V-HeFT VA Cooperative Studies Group. Circulation 1993; 87: VI65-70.
  33. Dubach P, Myers J, Bonetti P, Schertler T, Froelicher V, Wagner D, Scheidegger M, Stuber M, Luchinger R, Schwitter J and Hess O. Effects of bisoprolol fumarate on left ventricular size, function, and exercise capacity in patients with heart failure: analysis with magnetic resonance myocardial tagging. Am Heart J 2002; 143: 676-683.
  34. A placebo-controlled trial of captopril in refractory chronic congestive heart failure. Captopril Multicenter Research Group. J Am Coll Cardiol 1983; 2: 755-763.
  35. Matsumori A; Assessment of Response to Candesartan in Heart Failure in Japan (ARCH-J) Study Investigators. Efficacy and safety of oral candesartan cilexetil in patients with congestive heart failure. Eur J Heart Fail 2003; 5:669-677.
  36. Cicoira M, Zanolla L, Rossi A, Golia G, Franceschini L, Brighetti G, Marino P and Zardini P. Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol 2002; 40: 304-310.
  37. Suematsu Y, Miura S, Goto M, Matsuo Y, Arimura T, Kuwano T, Imaizumi S, Iwata A, Yahiro E and Saku K. LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice. Eur J Heart Fail 2016; 18: 386-393.
  38. Sengupta PP, Narula J. Reclassifying heart failure: predominantly subendocardial, subepicardial, and transmural. Heart Fail Clin. 2008; 4:379–382
  39. Claus P, Omar AM, Pedrizzetti G, Sengupta PP, Nagel E. Tissue tracking technology for assessing cardiac mechanics: principles, normal values, and clinical applications. JACC Cardiovasc Imaging. 2015; 8:1444–1460.
  40. Omar AMS, Bansal M, Sengupta PP. Advances in echocardiographic imaging in heart failure with reduced and preserved ejection fraction. Circ Res. 2016; 119:357–374.
  41. Sengupta P, Tajik J, Chandrasekaran K, Khanderia B: Twist mechanics of the left ventricle. Principles and application. JACC Cardiovasc Imaging 2008; 1: 366–376.
  42. Omar AMS, Vallabhajosyula S, Sengupta P: Left ventricular twist and torsion. Research observations and clinical applications. Circ Cardiovasc Imaging 2015; 8:e003029.
  43. Januzzi JL, Butler J, Fombu E, Maisel A, McCague K, Piña IL, Prescott MF, Riebman JB, Solomon S. Rationale and methods of the Prospective Study of Biomarkers, Symptom Improvement, and Ventricular Remodeling During Sacubitril/Valsartan Therapy for Heart Failure (PROVE-HF). Am Heart J. 2018 May; 199:130-136.