2.1. Subjects
The study involved 73 patients with HFrEF where they were randomly
assigned into two matched groups. Group (1) including 37 patients with
traditional treatment of heart failure and the other group (2) including
36 patients were treated with ARNI plus other evidenced based medical
treatments. Along the course of the study, 12 patients failed to be
followed up. So the final number of cases in the study who succeeded to
be followed up to 11 months were group (1) was 27 cases and group (2)
was 34 cases, Full history was taken, and full clinical examination was
done. Baseline vital signs, ECG, NYHA classification, conventional
echocardiography and STE were done at baseline study and after 6 and 9
months.