2.1 Prediction of lamin A-DNA and trf2- DNA interaction
DP-Bind, a web server for sequence-based prediction of DNA-binding residues in DNA-binding proteins was used in this study39. Human, lamin A, and trf2 protein sequences were retrieved from PubMed in FASTA format and performed for the prediction analysis. Briefly, the PSSM-based encoding was used by the DP-bind algorithm for the most accurate prediction. The results were documented and clearly showed through graphical representations using GraphPad Prism, Version 5.01.