3.6 Wild type and HGPS mutant lamin A analysis
Lamin A is a type V intermediate filament family protein, which is
present in the inner nuclear membrane of the nucleus. Human premature
lamin A has totally 664 amino acid residues, whereas mature lamin A has
646 amino acid residues, which forms functional lamin A and gives
structural integrity to nucleus and perform vital role in many signaling
pathways including interactions with telomeric protein complex. The
schematic representation of wild as well as HGPS mutant lamin A and
lamin C was shown in the (Figure 3) which clearly illustrates the
structural abnormalities between lamin A with missing of 39 amino acid
residues in HGPS mutant.