Lamins are intermediate filament protein located in the inner nuclear
membrane, which maintains the structural integrity and function of the
nucleus. we have examined the possible interactive role of wild as well
as mutant type lamin A in connection with telomere repeat binding
protein trf2. Briefly, bioinformatic prediction shows that lamin A has
strong interaction with telomeric complexes. DNA binding assay confirms
the strong interaction between wild type lamin A and telomeric DNA
sequences. Loss of 39 amino acids at C-terminal end of lamin A impairs
the nuclear structural integrity and induce chromosomal fusion. We
conclude that C-terminal 39 amino acids from tail domain of mature lamin
A possibly interact with trf2 and telomere, not lamin C and HGPS mutant
lamin A.