3.6 Wild type and HGPS mutant lamin A analysis
Lamin A is a type V intermediate filament family protein, which is present in the inner nuclear membrane of the nucleus. Human premature lamin A has totally 664 amino acid residues, whereas mature lamin A has 646 amino acid residues, which forms functional lamin A and gives structural integrity to nucleus and perform vital role in many signaling pathways including interactions with telomeric protein complex. The schematic representation of wild as well as HGPS mutant lamin A and lamin C was shown in the (Figure 3) which clearly illustrates the structural abnormalities between lamin A with missing of 39 amino acid residues in HGPS mutant.