FIGURE LEGENDS
Figure 1 . a) Clinical image at presentation: erythematosquamous
plaques affecting the skin of the right labia majora and ipsilateral
gluteus. b) Clinical detail: Superficial erosions on the surface of the
plaques separate white hiperkeratotic areas giving the characteristic
“cake-icing” or “strawberries and cream” appearance.
Figure 2 . Histopathology a) Punch skin biopsy - Hematoxylin and
eosin (10x): epidermal infiltration by large atypical cells with
eosinophilic, wide cytoplasm and prominent marginal nuclei, consistent
with Paget’s cells, in an acanthotic epidermis. b) Punch skin biopsy -
Hematoxylin and eosin (20x): Paget’s cells scattered throughout all
layers of epidermis, arranged predominantly in groups. c)
Immunohistochemistry CK7 stain: positive in skin Paget’s cells. d)
Immunohistochemistry CK20 stain: negative in skin Paget’s cells.