Acantholytic SCC
Overall, 17 patients were diagnosed with acantholytic variants of SCC. Sixteen of the patients were treated with primary surgery and one with primary RT. During the follow-up of the patient who had primary radiotherapy, recurrence was detected, and salvage total laryngectomy was performed. The patient is followed up disease-free. The information about the treatment modalities of the primary disease, recurrence, and treatment of recurrence is given in Table 3 .
Five of the patients were lost due to locoregional or systemic recurrence of the primary disease within the median 13 months (5-69). Furthermore, 2 patients died during the 6th and 12th years of the follow-up due to medical conditions other than primary disease. The remaining 9 patients were disease-free at their last follow-up.
The median follow-up duration is 30 months (5-158). 5-years disease-specific and overall survival rates are 72,8% and 60,7% respectively.