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Author contribution:
Alexandra L. Petrache – Performed immunofluorescence studies on mouse brains to characterise the expression of α5 GABAARs in different subtypes of interneurons, and assisted in preparing the manuscript.
Archie A. Khan- Designed and produced the new alpha 5 cell line and assisted in preparing the manuscript.
Alessandra Monaco – Synthesised and refined various analogues of alpha 5 NAMs with varying biological activity.
Martin W. Nicholson – Designed and produced the α5β2γ2-GABAAR stable cell line.
Martyna Kuta-Siejkowska - performed molecular docking and identification of the final conformation of the developed NAM.
Shozeb Haider - Computational modelling and assisted in preparing the manuscript.
Stephen Hilton – Developed, refined and synthesised the α5 compounds.
Jasmina N. Jovanovic – Supervised production and characterisation of all HEK293 cell lines stably expressing GABAARs which were used in this study.
Afia .B Ali – Designed and coordinated the project, performed and analysed all electrophysiology and neuroanatomy experiments, and prepared the manuscript.