Figure 1. (A-C ) Optimisation of α5IA to α5-SOP002. (D)Detailed interactions of α5-SOP002 at the GABA_AR binding site located at the interface between subunit α5 (blue) and γ2 (brown).(E) Surface representation of SH-AI-SOP002 (red) interacting with the α5 GABA_AR at the α5 (blue) and γ2 (brown) subunits’ interface. (F) Upper view of the α5 GABA_A subtype represented by ribbons. The red arrow points at α5-SOP002. Subunits α5 are shown in blue, β3 in green and γ2 in brown. (G) Surface and (H) ribbon representation of the α5 GABA_AR.