Figure
1. (A-C ) Optimisation of α5IA to α5-SOP002. (D)Detailed interactions of α5-SOP002 at the GABAAR binding
site located at the interface between subunit α5 (blue) and γ2 (brown).(E) Surface representation of SH-AI-SOP002 (red) interacting
with the α5 GABAAR at the α5 (blue) and γ2 (brown)
subunits’ interface. (F) Upper view of the α5
GABAA subtype represented by ribbons. The red arrow
points at α5-SOP002. Subunits α5 are shown in blue, β3 in green and γ2
in brown. (G) Surface and (H) ribbon representation of
the α5 GABAAR.