Authors' contribution

CC, IB, SC, DF, DB, RI, MC, MS, CC conceptualized the idea and collected
clinical data about patients, contributed to write and revise the paper.
VB and MM performed laboratory assessments, GC e RDS performed
statistical analysis of data. AG, GP, GWC, EH, and SDG critically
revised the manuscript. All authors read and approved the final
manuscript.

Acknowledgements

Thank you to Dr. Umberto Basile and Dr. Cecilia Napodano for the
scientific support in performing laboratory assessments.

Conflict of interest

The authors declare no conflict of interest for this manuscript.