Stratified analyses by age groups
We performed a sub-analysis using different age groups to assess the performance of diagnostic tests per age. Table 6 shows more details. For patients ≤ 2 years old sIgE to peanut was more specific (94%) than for other age groups thus in toddlers a positive sIgE can help rule in allergic disease. Ara h 2 was specific for all age groups but especially for those ≥ 16 years old where a positive result can accurately rule in allergy. sIgE to egg white was more specific in ≤ 2 years olds (95%) compared to ≤ 16 years olds where it only had 81% specificity for the diagnosis of raw HE allergy. For CMA, sIgE to CM and Casein had higher specificity (≥ 90 %) in the ≤ 16 year olds compared to SPT.