Hazelnut
sIgE to the cupin Cor a 9 and the 2S albumin Cor a 14 was strongly
associated with clinical symptoms in 161 Dutch hazelnut-sensitized
patients.273 sIgE to Cor a 9 and 14 allowed correct
diagnosis of 90% of severely hazelnut-allergic Belgian
children.274 In 423 hazelnut-allergic patients, Cor a
9 and 14 were associated with severe symptoms
(AUC=0.70).275 A model combining clinical symptoms and
sIgE to Cor a 14 and walnut increased the AUC to 0.91. In a prospective
multicenter study of 90 peanut and 44 hazelnut-allergic German children,
a 90% probability for a positive food challenge was calculated for Ara
h 2-specific IgE at 14.4 kU/L and for Cor a 14-specific IgE at 47.8
kU/L.276