Basophils |
Decrease in basophil activation post allergen-specific OIT
(CD63, CD203, histamine release) |
BAT, iBAT |
254-256 |
B cells
|
Induction of Breg cells on AIT,
Serological readouts: food, and allergen-specific IgE, IgG4
Epitope-specific IgE and IgG4
|
Flow cytometry,
ImmunoCAP, Eptiope mapping
|
170,234,243,257
|
T cells
|
Functional changes in tetramer positive/CFSElo/CD69+ CD40L+
allergen-specific CD4+ T cells,
Tracking Th2A cells
Decrease in T-cell derived type 2 cytokines
Epigenetic changes in T cell subsets (Tregs)
|
Flow and mass cytometry,
Luminex/ELISA,
pyrosequencing
|
258-263
|
Dendritic cells
|
Changes in costimulatory potential
(CD80, CD86)
|
Flow cytometry, DC-T cell co-culture
|
253,264
|