Non-food
Studies associating sIgE to allergens from multi-allergen non-food sources to clinical phenotypes are less in number. A study onArtemisia pollen allergy of 240 Chinese patients found that patients sensitized to three or four allergens had a higher risk of allergic asthma (56.4%) than patients sensitized to two or one (31.1%).286 Distinct sensitization patterns of 159 patients to dog, cat and horse allergens were associated with specific respiratory symptoms.287 Polysensitization to several house-dust mite allergens predicted current mite-related allergic rhinitis and current or future asthma.288
In conclusion, severe reactions to legume seeds and tree nuts are predominantly caused by sensitization to storage proteins rather than by pollen-related allergens such as Bet v 1 or profilin homologues, or nsLTPs (Table 3).
Table 3 : Specific IgE to these allergens is associated with severe symptoms