Hazelnut
sIgE to the cupin Cor a 9 and the 2S albumin Cor a 14 was strongly associated with clinical symptoms in 161 Dutch hazelnut-sensitized patients.273 sIgE to Cor a 9 and 14 allowed correct diagnosis of 90% of severely hazelnut-allergic Belgian children.274 In 423 hazelnut-allergic patients, Cor a 9 and 14 were associated with severe symptoms (AUC=0.70).275 A model combining clinical symptoms and sIgE to Cor a 14 and walnut increased the AUC to 0.91. In a prospective multicenter study of 90 peanut and 44 hazelnut-allergic German children, a 90% probability for a positive food challenge was calculated for Ara h 2-specific IgE at 14.4 kU/L and for Cor a 14-specific IgE at 47.8 kU/L.276