Drug combination No. R1 Mechanism/Effect Recommendations
Lopinavir/Ritonavir + Fluticasone/Salmeterol 7 F CYP3A4 inhibitors2 may increase the serum concentration of salmeterol Avoid combination or monitor for adverse effects of salmeterol
Lopinavir/Ritonavir + Tamsulosin 4 G CYP3A4 Inhibitors may increase the serum concentration of tamsulosin Avoid combination
Ipratropium Bromide/Salbutamol + Promethazine 2 F Increase the anticholinergic effects Avoid combination or monitor for anticholinergic related toxicity
Lopinavir/Ritonavir + Midazolam 2 E Protease Inhibitors may increase the serum concentration of midazolam Avoid combination or reduce doses of intravenous midazolam particularly if multiple doses are used