Identification of protein targets using PharmMapper
For identifying the protein targets of the thalidomide, we utilized the
PharmMapper server (http://www.lilab-ecust.cn/pharmmapper/) . The
server identifies possible physiological protein targets of any drug
molecule by using a pharmacophore-based mapping approach. The
three-dimensional structure of thalidomide was obtained from PubChem and
processed on the PharmMapper server choosing only human protein target
sets. The top 100 target proteins were selected based on the ranking
associated with a fit score (pKd value) for further enrichment analysis
using Enrichr .
Results