Similarity of SARS-coV-2 expression profile with that of SLE,
lymphoma and multiple myeloma
Comparative enrichment analysis of gene expression profiles for
disease-specific phenotypes revealed the similarity of SARS-infected
tissues with pneumonia, influenza, lymphoma, systemic lupus
erythematosus (SLE), multiple myeloma, asthma, auto-immune diseases,
asthma, pneumonia, and atherosclerosis while SARS-coV-2 PBMC showed
exclusive overlap with lymphoma, multiple myeloma and chronic
lymphocytic leukemia (CLL) (Figure 6A). The gene expression profile of
SARS-coV-2 infected lungs was very similar to that of PBMC from SLE
patients (Figure 6C). There was a significant overlap between SARS-coV-2
and SLE in up-regulated genes involved in immune regulation (Figure 3B),
interferon signaling (Figure 5B) and disease-specific phenotypes (Figure
6B, 6D, 6E). Many genes deregulated in lymphoma and multiple myeloma
were up-regulated in SARS-coV-2 infections as well (Figure 6B, 6E).
Several aberrantly expressed genes involved in these disease phenotypes
were down-regulated in thalidomide and lenalidomide treated A549 and
endothelium (Figure 6).