Haplotype analysis and association with event
The LD block and the haplotype structure were measured by D’ and R2, and the final LD analysis revealed two haplotypes in our patients. Two SNPs of rs41273215 and rs57731889 in PEAR1 are in Block 1, and rs1126643 and rs1062535 in ITGA2 are in Block 2 (Figure 1 ). The significance of any haplotypic association is shown in Table 4 . In Block 2, the linked variant alleles were observed most frequently as the GC haplotype (frequency 0.700) and AT haplotype (frequency, 0.278). Both GC and AT haplotypes showed a significant impact on the recurrence of adverse events. No other haplotype was associated with the risk of clinical events