Haplotype analysis and association with event
The LD block and the haplotype structure were measured by D’ and
R2, and the final LD analysis revealed two haplotypes
in our patients. Two SNPs of rs41273215 and rs57731889 in PEAR1 are in
Block 1, and rs1126643 and rs1062535 in ITGA2 are in Block 2
(Figure 1 ). The significance of any haplotypic association is
shown in Table 4 . In Block 2, the linked variant alleles were
observed most frequently as the GC haplotype (frequency 0.700) and AT
haplotype (frequency, 0.278). Both GC and AT haplotypes showed a
significant impact on the recurrence of adverse events. No other
haplotype was associated with the risk of clinical events