Results
The incidence of asthma was 10.8 per 1,000 person-years in the
constipation group, which was higher than the rate of 5.6 per 1,000
person-years observed in the non-constipation group. After adjustment
for age, gender, comorbidities, and medications, constipated patients
had a 1.91-fold greater risk of asthma compared to those without
constipation (adjusted hazard ratio [aHR]: 1.91 (95% C.I.
1.84-1.99). In subgroup analyses, patients aged 20-39 years had a
2.04-fold highest risk of asthma in the constipation cohort (aHR:2.04,
95% CI, 1.84-2.26). Besides, the severity of constipation is associated
with an increased risk of asthma; the aHR was 1.76 (1.69-1.85),
2.15(2.03-2.27), and 2.29(2.10-2.49) for < 3 times, 3-12
times, and ≥12 times of laxatives prescription within one year,
respectively. (p<0.001) Moreover, constipated patients had a
higher likelihood of asthma, regardless of gender, comorbidities, and
medications.