RESULTS
The study included 37 patients, 24 were females (64.9%) and 13 males (35.1%) (mean age of 55.2±22.4 years). The time interval between drug administration and onset of symptoms was 103.3±132.8 hours, and between onset of symptoms and sample collection was 160±186 days. The most frequent clinical entities were MPE, in 21 (56.8%), and SJS-TEN, in 10 (27%), followed by AGEP (acute generalized exanthematous pustulosis) in 3 cases (8.1%), DRESS in 2 cases (5.4%), and FDR (fixed drug reaction) in 1 case (2.7%). The most frequent drugs implicated in the reactions were BLs in 14 (37.8%), RCM in 11 (29.73%), quinolones in 4 cases (10.81%) and in a lower degree xanthine oxidase inhibitors, anticonvulsants and sulphonamides in 2 cases each (5.4%), and benzodiazepines and ferrous supplement in 1 case each (2.7%). Thirteen (35%) cases were diagnosed by ST (10 IDT and 3 PT), 13 (35%) by DPT, and 11 (30%) by the ASPS (Table 1). Additionally, 21 sex- and age-matched healthy controls with tolerance to drugs were included.