Laboratory parameters of WH and NWH patients
We next compared laboratory data of these two groups of patients at
hospital admission, midterm (7-15 days after their admission), and
discharge. We observed that there were no obvious differences in
pulmonary function parameters although the level of lactic acid was
higher in WH patients at hospital admission and discharge (Supplemental
Figure 1). Although there were no significant differences in the levels
of total bilirubin, direct bilirubin, alanine aminotransferase (ALT) and
glutamic oxalacetic transaminase (AST), the levels of blood urea
nitrogen (BUN) and creatinine (Crea) were increased in WH patients at
the hospital midterm and admission respectively (Supplemental Figure 2).
From the measurement of blood coagulation, we observed a significantly
longer time of activated partial thromboplastin time (APTT) in WH
patients at hospital admission and midterm (Supplemental Figure 3).
Procalcitonin (PCT) and C reactive protein (CRP) and interleukin-6
(IL-6) were not significantly different between the two groups
(Supplemental Figure 4). The viral load of the two groups had no
significant difference at hospital admission, and midterm (Figure 1B),
but the viral duration of WH patients was longer than that of NWH
patients (P<0.05) (Figure 1C). In the hemogram record, WH
patients had lower lymphocyte counts than NWH patients at hospital
midterm and lower platelet counts at hospital admission and midterm
(Supplemental Figure 5). We further found that WH patients had lower
levels of CD3+, CD4+ and
CD8+ T cells in peripheral blood than NWH patients at
all the three checks, hospital midterm and discharge, and hospital
midterm respectively (Figure 2A-C).