Declarations
Funding This work was supported by The Special Fund for Education and Scientific Research of Fujian Provincial Department of Finance (2019-926) and The National Key Research and Development Program of China (2016YFC0901503).
Conflicts of interest None declared.
Ethics approval The Ethics committee of the Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College approved the study (CAMS-2005/CAMS-2009, NCT03165851).
Consent for participateParental/guardian of all patient consent for participate.
Consentfor publication Parental/guardian of all patient consent for publication.
Availability of data and materialthe raw data were uploaded as a supplementary material.
Author’s contributions ALZ and LPL conceived and designed the study. ALZ and LPL drafted the initial manuscript and analyzed the data. MR, XYC, and CL reviewed the initial manuscript. CYW and YCZ supervised the work. LXC, XJC, WYY, YG, LZ, YZ, and YMC collected and provided patient clinical data. XFZ and MR assigned the protocol, and critically revised the manuscript for relevant intellectual content. All authors approved the final submitted version of the paper.
Acknowledgements All authors express thanks to Dr Meihui Yi, Yang Lan, Luyang Zhang, Yuli Cai, Jing Feng, Wenqi Wu. We want to acknowledge patients and their families for participating in the follow-up.