Declarations
Funding This work was supported by
The
Special Fund for Education and Scientific Research of Fujian Provincial
Department of Finance
(2019-926)
and
The
National Key Research and Development Program of China
(2016YFC0901503).
Conflicts of interest None declared.
Ethics approval The Ethics committee of the Institute of
Hematology and Blood Diseases Hospital, Chinese Academy of Medical
Sciences and Peking Union Medical College approved the study
(CAMS-2005/CAMS-2009,
NCT03165851).
Consent for participateParental/guardian
of all patient consent for participate.
Consentfor publication Parental/guardian of all patient consent for
publication.
Availability of data and materialthe
raw data were uploaded as a supplementary material.
Author’s contributions ALZ and LPL conceived and designed the
study. ALZ and LPL drafted the initial manuscript and analyzed the data.
MR, XYC, and CL reviewed the initial manuscript. CYW and YCZ supervised
the work. LXC, XJC, WYY, YG, LZ, YZ, and YMC collected and provided
patient clinical data. XFZ and MR assigned the protocol, and critically
revised the manuscript for relevant intellectual content. All authors
approved the final submitted version of the paper.
Acknowledgements All authors express thanks to Dr Meihui Yi,
Yang Lan, Luyang Zhang, Yuli Cai, Jing Feng, Wenqi Wu. We want to
acknowledge patients and their families for participating in the
follow-up.