Statistical analysis
Progression-free survival (PFS) and OS were the primary endpoints of the
study. PFS referred to the time from the beginning of treatment to
disease progression or death. OS was defined as the time of death due to
any cause. Categorical variables are expressed as total numbers and
percentages. Because the continuous variables are not normally
distributed, median, minimum and maximum values were used as descriptive
statistics. Clinical characteristics,
complete
remission (CR) rate, and mortality rate-related variables were compared.
Categorical variables were compared using χ2 test,
likelihood ratio χ2 or Fisher’s exact test, and
differences in continuous variable were compared
using
nonparametric Mann–Whitney U-test. For the logistic proportional hazard
regression models, the results were expressed as
odds
ratios (ORs), 95% confidence intervals (CIs) and P -values.
Variables with P <.10 in univariate analysis were
included in this model for multivariate
analysis.P <.05 indicated statistical significance. The PFS and
OS rates were estimated by Kaplan-Meier survival analysis, and the
log-rank test was used for survival comparison. All tests were 2-sided.
SPSS 25 was used for all statistical analyses.