Patients
A total of 139 consecutive pediatric patients with newly diagnosed LCH
were admitted to our hospital between January 1, 2020, and June 30,
2021. One hundred and fourteen patients with available plasma samples
were prospectively enrolled in the present study cohort. Twenty-five
patients were excluded due to loss to follow-up after diagnosis (n = 18)
or lack of plasma samples (n = 7). This study was approved by the
Beijing Children’s Hospital Ethics Committee and was conducted in
accordance with the Declaration of Helsinki. Informed consent was
obtained from the guardians of the patients.