Statistical analysis
All parameters were compared between patient groups by the χ2 test, t test, one-way ANOVA, and post hocTukey’s test according to the scale of the variable. For skewed data, a nonparametric test (Mann‒Whitney U test) or one-way ANOVA and Tukey’s test were applied after log transformation. To assess the correlation between sCSF1R and other parameters, Spearman’s rank correlation coefficient (rS) was computed. Progression-free survival (PFS) was evaluated from the date of diagnosis until the date of one of the following events: progression, relapse, or death, whichever came first. PFS was estimated using the Kaplan–Meier method and compared with the log-rank test between subgroups. The prognostic value of plasma sCSF1R levels was studied using univariate and multivariate Cox models. AllP values are shown as the results of two-sided tests. A Pvalue < 0.05 was considered to indicate statistical significance. All the statistical analyses were performed by M Salama using SPSS software version 29.0 (SPSS, Inc., IL).