Study selection and data extraction
An information specialist/methodologist (CS) searched five databases
using a search strategy developed with clinicians and patient
representatives (see online supplement S1). Two methodologists
identified additional references by searching the reference lists of
previous reviews, guidelines and identified studies and seeking
recommendations from experts (CS, DdS). Two methodologists independently
screened titles and abstracts and the full text of any studies deemed
potentially relevant (CS, DdS). Shortlisted studies were rescreened by
all clinicians, allied health professionals and patient representatives
on the task force (all authors). We excluded studies where it was
unclear that the reactions described were anaphylaxis (see online
supplement S2). There was 100% inter-rater agreement about the studies
included.
Data about study characteristics and outcomes were extracted into a
template independently by two methodologists (CS, DdS) and by task force
members divided into small topic groups (all authors).