This analysis, using published authentic data, will explore the existing/ guided strategy of the global mass vaccination program to combat the COVID-19 crisis.  It mainly focused on countries that experienced unprecedented deaths in the later period and the period covered is till 21st March 2022. The peak of deaths in later months reached an all-time high since the beginning of the pandemic. Nine countries identified in that category are Singapore, South Korea, Australia,  Hong Kong,  Iceland,  New Zealand, Denmark,  Finland and Japan. Almost all of those countries had nominal cases and deaths prior to September 2021 (vaccine third dose was initiated). Interestingly, all those nine countries had very high vaccination rates and were among the topmost vaccinated countries during the covered period. Israel started mass vaccination first and initiated the fourth dose at the beginning of January 2022; soon afterward, not only cases but also, deaths reached an all-time high. Israel also introduced vaccine doses among children of various age groups first and was in fact, leading or guiding the vaccine roll-out strategy. Gibraltar on the other hand implemented the most successful mass vaccination programme, from the beginning. Gibraltar was the country that achieved the highest target for vaccination at the earliest. It attained and maintained 100% vaccination since May 2021, though cases of the latest peak in March 2022 reached an unprecedented high for the whole of the pandemic. All the data analysed here started from the beginning of the pandemic and was presented using government official COVID tool Ourworldindata. Moreover, cases as well as deaths in later periods among vaccinated groups, were also compared with the unvaccinated ones, for the UK, based on the country’s government report. That indicated an unusual surge of cases and deaths in later periods among vaccinated groups compared to the unvaccinated ones.  Various observed facts, supported by well-known and established scientific theories, indicate that high vaccination may weaken natural immune response which needs urgent policy action.