Abstract
The dynamic protrusions of lamellipodia and filopodia have emerged as
crucial players in tumor progression and metastasis. These membrane
structures, governed by intricate actin cytoskeletal rearrangements,
facilitate cancer cell migration, invasion, and interaction with the
tumor microenvironment. This review provides a comprehensive examination
of the structural and functional attributes of lamellipodia and
filopodia, shedding light on their pivotal roles in mediating cancer
invasion. Navigating through the intricate landscape of cancer biology,
the review illuminates the intricate signaling pathways and regulatory
mechanisms orchestrating the formation and activity of these
protrusions. The discussion extends to the clinical implications of
lamellipodia and filopodia, exploring their potential as diagnostic and
prognostic markers, and delving into therapeutic strategies that target
these structures to impede cancer progression. As we delve into the
future, the review outlines emerging technologies and unexplored facets
that beckon further research, emphasizing the need for collaborative
efforts to unravel the complexities of lamellipodia and filopodia in
cancer, ultimately paving the way for innovative therapeutic
interventions.
Keywords: Lamellipodia; filopodia; cancer invasion; metastasis;
mechanobiology