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\begin{document}

\title{The microRNA cluster including miRNA16, miRNA27 and miRNA103 represents
an early peripheral biomarker of fetal growth restriction}



\author[1]{Salvatore Tagliaferri}%
\author[1]{Pasquale Cepparulo}%
\author[1]{Antonio Vinciguerra}%
\author[1]{Marta Campanile}%
\author[1]{Giusy Esposito}%
\author[1]{Giuseppe Maruotti}%
\author[1]{Fulvio Zullo}%
\author[1]{Lucio Annunziato}%
\author[1]{GIUSEPPE PIGNATARO}%
\affil[1]{University of Naples Federico II School of Medicine and Surgery}%


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  \date{May 17, 2024}


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\begin{abstract}
Objective: Current tests available to diagnose fetal hypoxia in-utero
lack sensitivity thus un-diagnosing many fetuses at risk. microRNAs
derived from the placenta circulate in the maternal blood during
pregnancy and may be used as biomarkers for pregnancy complications. To
identify putative markers of fetal growth restriction (FGR) and new
therapeutic druggable targets, we examined, in maternal blood samples,
the expression of a cluster of microRNAs, known to be regulated by
hypoxia. Population: Pregnant Caucasian women between 18 and 46 years
old hospitalized. Design and Setting: To discriminate between early- and
late-onset FGR, the study population was divided into two subgroups
according to the gestational age at delivery, group (1) :
\textless{}32th weeks of gestation; and group (2) from 32th to 37th
weeks of gestation. Methods: Ultrasound biometry, Doppler velocimetry,
RT-PC-R, Software miRNA-targets predictors Results: Among the microRNA
cluster examined, three microRNAs: miR-16-5p, miR-103-3p, and miR-27b-3p
were upregulated in FGR blood samples before the 32th week of gestation.
Notably, the expression of all miRNAs was increased through gestation in
healthy control group, whereas, in the FGR groups, where there was a
progressive reduction in the expression of miR-103-3p and miR-107-3p and
a slight reduction for miR-16-5p. Main Outcome Measures: miRNA
expression Conclusions: Our results showed that measurement of miRNAs in
maternal blood may form the basis for a future diagnostic test to
determine the degree of fetal hypoxia in FGR, thus allowing the start of
appropriate therapeutic.%
\end{abstract}%



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\verb`Tagliaferri et al, 2020.doc`  available at \url{https://authorea.com/users/344222/articles/470871-the-microrna-cluster-including-mirna16-mirna27-and-mirna103-represents-an-early-peripheral-biomarker-of-fetal-growth-restriction}\selectlanguage{english}
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