Incidence of and Risk Factors for development of AKI in Patients Hospitalized with Salicylate Intoxication
Between 2003 and 2014 there were 13,805 admissions with a primary diagnosis of salicylate intoxication. A total of 18 patients with end stage renal disease were excluded, a total of 13,787 admissions were included in the study. Of these, 1,279 (9.3%) had an AKI. Overall, among patients with salicylate intoxication, AKI was more commonly present in patients who were male, Caucasian, older and had associated comorbidities and acute conditions (Table 1 ). Multivariable analysis identified older age (OR 1.90 for age 20-29 years, 2.93 for age 30-39 years, 4.54 for age≄40 years; all p<0.001), male sex (OR 2.59; p<0.001), more recent period of hospitalization (OR 2.23 for year 2007-2010, and 3.19 for year 2011-2014; all p<0.001), anemia (OR 2.31; p<0.001), hypertension (OR 1.19; p=0.03), congestive heart failure (OR 1.67; p=0.002), chronic kidney disease (OR 7.00; p<0.001), volume depletion (OR 3.48; p<0.001), sepsis (OR 5.61; p<0.001), and ventricular arrhythmia/cardiac arrest (OR 1.72; p=0.04) as clinical characteristics significantly associated with increased risk of developing AKI, and Hispanic race (OR 0.70; p-0.01) as clinical characteristics significantly associated with decreased risk of AKI (Table 2).