Incidence of and Risk Factors for development of AKI in Patients
Hospitalized with Salicylate Intoxication
Between 2003 and 2014 there were 13,805 admissions with a primary
diagnosis of salicylate intoxication. A total of 18 patients with end
stage renal disease were excluded, a total of 13,787 admissions were
included in the study. Of these, 1,279 (9.3%) had an AKI. Overall,
among patients with salicylate intoxication, AKI was more commonly
present in patients who were male, Caucasian, older and had associated
comorbidities and acute conditions (Table 1 ). Multivariable
analysis identified older age (OR 1.90 for age 20-29 years, 2.93 for age
30-39 years, 4.54 for ageā„40 years; all p<0.001), male sex (OR
2.59; p<0.001), more recent period of hospitalization (OR 2.23
for year 2007-2010, and 3.19 for year 2011-2014; all p<0.001),
anemia (OR 2.31; p<0.001), hypertension (OR 1.19; p=0.03),
congestive heart failure (OR 1.67; p=0.002), chronic kidney disease (OR
7.00; p<0.001), volume depletion (OR 3.48; p<0.001),
sepsis (OR 5.61; p<0.001), and ventricular arrhythmia/cardiac
arrest (OR 1.72; p=0.04) as clinical characteristics significantly
associated with increased risk of developing AKI, and Hispanic race (OR
0.70; p-0.01) as clinical characteristics significantly associated with
decreased risk of AKI (Table 2).