Literature search
Two authors (Q.Y.Q and W.K.E) independently performed a systematic search of PubMed, Web of Science, Clinical Trials.gov, and Cochrane Library for English-language studies up to May 30, 2020. Comprehensive searching was conducted using the terms: “glucokinase activator” and “type 2 diabetes”. We also performed a systematic search of the Chinese National Knowledge Infrastructure (CNKI) (http://www.cnki.net/)for Chinese-language studies. Our study is registered on PROSPERO (CRD42020188517) and conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.