Conclusion

Real-world data for AIT complement those from randomized controlled trials. The RWE studies summarized in this review demonstrated the effectiveness of AIT in hampering the progression of rhinitis and asthma and onset of asthma for AIT with different allergens, AIT products, and for different age groups in daily practice. Data for medication adherence are more true-to-life when based on real-world data but due to divergent adherence definitions there are no consistent results in the different real-world assessments. Regulatory authorities are currently developing standards for generating and assessing RWE data to support regulatory decision-making for drug and biological products.