Health-related quality of life
The impact on health-related quality of life as measured by RQLQ was significantly reduced during the birch and grass pollen seasons regardless of active ILIT with birch, 5-grass or both allergens. When combining all three groups, the RQLQ score was significantly reduced from 3.15 to 1.50 (-52%) and from 2.82 to 1.25 (-56%) three years after treatment during the birch and grass pollen seasons, respectively (p<0.01, Fig. 2a-b, Table S1 in the Supplementary information).