FIGURE 4 Proportion (%) of the T regulatory (Treg) cells in
the CD3+CD4+ populations after
intralymphatic immunotherapy with birch and/or 5-grass allergen. Blood
samples were collected at three timepoints: screening, one year after,
and three years after treatment had finished. The proportion of Treg
cells, defined as
CD4dimCD25hiFoxP3+cells, increased over time in all treatment groups (a-c). The same trend
was observed in the activated Treg cell population, defined as
CD3+CD4+CD45RA-FoxP3++(d-f). p* < 0.05; p** < 0.01; p*** < 0.001
from Wilcoxon signed rank tests. The lines indicate median and
interquartile range (IQR, 25th and
75th percentile values).