Secondary outcome measures
Effects on quality of life were measured using the rhinoconjunctivitis
quality of life questionnaire (RQLQ) 22 recorded as
RTSS and MS, see above. Skin prick test reactions (Soluprick SQ Birch
and Timothy, ALK-Abelló), allergen-specific IgE and allergen-specific
IgG4 levels were analyzed (ImmunoCAP ThermoFisher, Uppsala, Sweden)
before ILIT and in the fall the following three years. Conjunctival
allergen provocation tests (CAPT) 23 were performed
with timothy (Aquagen SQ Timothy, ALK-Abelló) before treatment and after
the first pollen season after treatment. Due to lack of extract from the
company planned CAPT were not performed after the third pollen season
(Table 2).