Adverse events
A total of 438 injections were given, of which 285 had an active
substance containing allergen extract. Mild local pain at the injection
site was the most common adverse event (AE). However, on three
occasions, patients recorded severe pain from ILIT. One patient had
moderate breathing problems without any fall in peak flow 30 minutes
after the second ILIT (birch and 5-grass) and received the third
treatment without any AEs. One patient experienced breathing problem two
hours after physical activity, four days after the first injections, and
was relieved with salbutamol inhalations, antihistamine and oral
corticosteroids. The remaining injections followed without breathing
problems. During the follow-up after ILIT, nine patients reported severe
AEs, diverticulitis, miscarriage, burn injury, disc hernia, abdominal
pain, hysterectomy, concussion, chest pain, and heart failure but none
was judged to be related to ILIT. One patient showed hypothyroidism with
elevated levels of antithyroid peroxidase, and thyroid-stimulating
hormone receptor antibodies diagnosed in 2018, possibly related to the
therapy given in 2014.