Adverse events
A total of 438 injections were given, of which 285 had an active substance containing allergen extract. Mild local pain at the injection site was the most common adverse event (AE). However, on three occasions, patients recorded severe pain from ILIT. One patient had moderate breathing problems without any fall in peak flow 30 minutes after the second ILIT (birch and 5-grass) and received the third treatment without any AEs. One patient experienced breathing problem two hours after physical activity, four days after the first injections, and was relieved with salbutamol inhalations, antihistamine and oral corticosteroids. The remaining injections followed without breathing problems. During the follow-up after ILIT, nine patients reported severe AEs, diverticulitis, miscarriage, burn injury, disc hernia, abdominal pain, hysterectomy, concussion, chest pain, and heart failure but none was judged to be related to ILIT. One patient showed hypothyroidism with elevated levels of antithyroid peroxidase, and thyroid-stimulating hormone receptor antibodies diagnosed in 2018, possibly related to the therapy given in 2014.